Affinergy

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About Us

  • Technology
  • Peptides
  • Applications
  • Compliance
  • History
  • Careers




  • Affinergy, located in Research Triangle Park, NC, is developing cutting edge assays and research tools that will lead to improved scientific and diagnostic outcomes. We strive to deliver innovative and effective products that meet the demanding and evolving needs of the medical and scientific communities.




    Core Technology




    Affinergy discovers peptides that capture, deliver, and retain specific proteins, drugs, or cells. Using our core technology, phage display biopanning, we screen proprietary libraries of peptide sequences comprising 95 billion unique sequences and structures.

    These screens lead to the discovery of peptides with high affinity and specificity for their targets. We have discovered a comprehensive panel of peptides for a variety of proteins, cell types, and antibiotics.

    In addition, we have developed chemistries for immobilizing these peptides on a wide variety of solid substrates, including magnetic beads, agarose resin, collagen meshes, glass slides, silicone, ePTFE, and titanium.

    Recent publications:





    Example Peptides




    Affinergy has discovered proprietary peptides that bind with high affinity and specificity to multiple targets, including the following:

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    Growth Factors:

    • BMP-2 and BMP-7

    • PDGF-BB

    • TGFβ3

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    Cells:

    • Mesenchymal Stem Cells

    • Fibroblasts

    • Epithelial Cells

    • Cardiomyocytes

    • Regulatory T cells

    • Monocytes

    • Hepatocytes

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    Antibiotics:

    • Vancomycin





    Applications




    Affinergy's product development pipeline encompasses a range of peptide-based technologies:


    Assay Development

    • Peptides capture proteins, drugs, or biomolecules from complex solutions

    • Captured analytes can be quantified using standard detection methods

    • Peptides can be tagged with unique labels ("barcodes"), creating multiplexed assays to simultaneously identify and quantify large numbers of target biomolecules

    Sample Preparation

    • Peptides capture proteins from biological samples (blood, urine, culture media, etc.)

    • Technology enables one-step removal of unwanted/contaminating proteins, or one step enrichment of low-abundance proteins of interest

    • Proteins can be eluted from the peptide for down-stream analysis or processing

    Cell Sorting

    • Peptides isolate or purify target cell types from mixed populations

    • Cells can be isolated from blood, tissue digests, urine, and other biological fluids

    • Technology is being developed for rare cell recovery, cell purification kits, and therapeutic apheresis devices

    Diagnostic Tests

    • Peptide coatings are used to develop cell-based in vitro diagnostic (IVD) tests

    • Target cell types are selectively captured, while non-target/obscuring cells do not adhere and can be washed away

    • Peptide does not interfere with characterization of captured cells by cytology, immunocytochemistry, FISH, or qPCR

    Affinergy's products are not currently approved by the U.S. Food and Drug Administration.





    Compliance




    Click here to view Affinergy's Financial Conflict of Interest Policy.





    History




    Affinergy was spun out of Duke University in 2004 based on technology developed by Daniel Kenan, MD, PhD and Mark Grinstaff, PhD. Additional co-founders include Jonathan Gindes and Peyton Anderson. Affinergy has benefited from the support of the NC Biotechnology Center, the Council for Entrepreneurial Development, the National Institutes of Health, and a talented team of advisors. Dr. Bruce Lamb joined Affinergy in 2009 to lead all product development activities as our SVP of R&D. Affinergy currently employs approximately 25 professionals and has an extensive network of consultants and advisors.




    Affinergy is grateful to the following institutes for funding its research endeavors:

    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    National Institute of Dental and Craniofacial Research

    National Institute of General Medical Sciences

    National Heart, Lung, and Blood Institute

    National Institute of Allergy and Infectious Diseases

    National Institute of Diabetes and Digestive and Kidney Diseases

    National Institute of Neurological Disorders and Stroke






    Career Opportunities




    Please note that Affinergy does not work with recruiting agencies

    Affinergy offers a great opportunity to join a dedicated team of visionary scientists and proven entrepreneurs committed to growing the Company's technology platform and improving the quality of products in many important industries. Affinergy has a state of the art 11,000 sq ft facility located in Durham, NC adjacent to the Research Triangle Park.




    Current Job Openings:


      There are no job openings available at this time



    Contact Information:

    Human Resources Department
    Affinergy, LLC
    PO Box 14650
    RTP, NC 27709
    Fax: 919-474-9407
    Email:


    Please visit our website at www.affinergy.com