About Us

Affinergy, located in Research Triangle Park, NC, is developing products to improve clinical and diagnostic outcomes for a broad spectrum of patients while delivering safe and effective products for use by clinicians and investigators.

Core Technology

Affinergy discovers peptides that can capture, deliver, and retain specific proteins, drugs, or cells. Using our core technology, phage display biopanning, we screen proprietary libraries of peptide sequences comprising 95 billion unique sequences and structures.

These screens lead to the discovery of peptides with high affinity and specificity for their targets. We have discovered a comprehensive panel of peptides for a variety of proteins, cell types, and antibiotics.

In addition, we have developed chemistries for conjugating these peptides to various types of devices, including bone void fillers, hernia meshes, metal implants, and glass slides.

Example Peptides

Affinergy has discovered proprietary peptides that bind with high affinity and specificity to multiple targets including the following:

Growth Factors:

• BMP-2 and BMP-7

• PDGF-BB

• TGFβ3

Cells:

• Mesenchymal Stem Cells

• Fibroblasts

• Cardiomyocytes

• Regulatory T cells

Antibiotics:

• Vancomycin

Applications

Affinergy's high affinity peptides have a broad range of applications for implantable devices, diagnostics, and biotech research tools including:

• Slowing the release of growth factors in vivo

• Capturing and concentrating cells from biological fluid and tissue

• Sorting and purifying specific cell types

• Depleting cells or proteins from blood

• Labeling cells in vivo or in vitro

Affinergy's products are not currently approved by the U.S. Food and Drug Administration.

Compliance

Click here to view Affinergy's Financial Conflict of Interest Policy.

History

Affinergy was spun out of Duke University in 2004 based on technology developed by Daniel Kenan, MD, PhD and Mark Grinstaff, PhD. Additional co-founders include Jonathan Gindes and Peyton Anderson. Affinergy has benefited from the support of the NC Biotechnology Center, the Council for Entrepreneurial Development, the National Institutes of Health, and a talented team of advisors. Dr. Bruce Lamb joined Affinergy in 2009 to lead all product development activities as our SVP of R&D. Affinergy currently employs approximately 25 professionals and has an extensive network of consultants and advisors.

Affinergy is grateful to the following institutes for funding its research endeavors:

National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Institute of Dental and Craniofacial Research

National Institute of General Medical Sciences

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Neurological Disorders and Stroke

Career Opportunities

Please note that Affinergy does not work with recruiting agencies

Affinergy offers a great opportunity to join a dedicated team of visionary scientists and proven entrepreneurs committed to growing the Company's technology platform and improving the quality of products in many important industries. Affinergy has a state of the art 11,000 sq ft facility located in Durham, NC adjacent to the Research Triangle Park.

Current Job Openings:

• GRANT WRITER
  Research Triangle Park, NC

  
  

• PRODUCT ANALYST, RESEARCH PRODUCTS
  Research Triangle Park, NC

  
  

Contact Information:

Human Resources Department
Affinergy, LLC
PO Box 14650
RTP, NC 27709
Fax: 919-474-9407
Email:


Please visit our website at www.affinergy.com